THE ASSOSIATION CORTISOL LEVELS OF MATERNAL BETWEEN PRETERM AND ATERM LABOR

Abstract

ABSTRACT

Preterm labor is a problem that needs great attention because of its impact on perinatal morbidity and mortality. Every year, 15 million babies are born prematurely. The World Health Organization (WHO) estimated in 2003 a 10.5% BBLR incidence, an IUGR of 19.8%, and a preterm labor of 18.5%. Preterm labor still being problem of health that needs great attention because its impact on perinatal morbidity and mortality. Chronic stress during pregnancy will lead to an increase and release of hormones that play a role in childbirth, including CRH, ACTH, cortisol, prostaglandin, and other hormones that play a role to initiate the onset of labor. This may lead to an increased risk of preterm birth. The aim of the research is to find out the association between cortisol levels of mother with preterm and aterm labor. This study is an observational research with cross-sectional design. The study was conducted at Regional public hospital Dr. Rasididin Padang, Regional public hospital Prof. Dr. MA Hanifiah SM Batusangkar, Central public hospital M. Djamil Padang. The number of samples 50 respondents selected by consecutive sampling is divided into 2 groups, 25 respondents with aterm labor and 25 preterm respondents. Examination of cortisol levels was performed at the Biomedical Laboratory of Andalas University of Padang by using ELISA method. Normality test with Shapiro-wilk and analysis applied using chi-square test. The mean level of cortisol in preterm is higher than aterm. There is a association between cortisol levels with preterm dan aterm labor (p = 0,02; p < 0,05). The results found that there was a relationship between between cortisol levels with preterm dan aterm labor in Padang City. High levels of cortisol lead to an increased risk of preterm labor. 

Keyword : Stress maternal, Cortisol, preterm labor