TOKSISITAS LOGAM TIMBAL TERHADAP KESEHATAN DAN LINGKUNGAN: LITERATUR REVIEW
Abstract
ABSTRAK
Artikel ini membahas tentang toksisitas logam timbal terhadap kesehatan manusia dan lingkungan. Dalam artikel ini, metode sistematis literature review (SLR) digunakan untuk mengumpulkan dan menganalisis data terkait toksisitas timbal. Penelitian ini mengungkap beberapa dampak buruk toksisitas timbal terhadap tubuh manusia, termasuk keracunan timbal yang dapat menyebabkan kerusakan pada hati, neurologis, ginjal, sistem reproduksi, gangguan perkembangan pada anak-anak, dan masalah kesehatan lainnya. Artikel ini juga membahas dampak toksisitas timbal terhadap lingkungan, di mana penggunaan timbal yang tidak terkontrol dapat mencemari tanah, air, dan udara. Dampak ini berpotensi merugikan ekosistem dan organisme hidup di sekitarnya. Penggunaan timbal dalam industri dan praktik ilegal lainnya juga menjadi sorotan, karena dapat menyebabkan keracunan timbal pada konsumen. Untuk mengatasi masalah toksisitas timbal, langkah-langkah pengendalian yang efektif direkomendasikan, termasuk penggunaan pengganti timbal yang lebih aman, pengawasan ketat terhadap penggunaan timbal dalam industri, dan edukasi masyarakat tentang bahaya toksisitas timbal. Penelitian lebih lanjut juga ditekankan untuk memahami dampak toksisitas timbal secara mendalam dan mengembangkan solusi yang lebih efektif. Kesimpulannya, toksisitas timbal merupakan masalah serius yang membutuhkan perhatian dan tindakan segera, dengan memahami dampak buruknya sehingga dapat mengambil langkah-langkah pengendalian yang tepat untuk melindungi kesehatan manusia dan lingkungan dari dampak negatif logam berat ini.
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ATSDR. (2020). Toxicological Profile for Lead. In ATSDR’s Toxicological Profiles (Issue August). https://doi.org/10.1201/9781420061888_ch106
Bellinger DC. (2004). Lead. Pediatrics 113 (4 Suppl): 1016–1022. Bellinger DC. (2005). Teratogen update: lead and pregnancy. Birth Defects Res A Clin Mol Teratol 73: 409–420.
Bellinger DC. (2008). Very low lead exposures and children’s neurodevelopment. Curr Opin Pediatr 20: 172–177.
Benjelloun M, Tarrass F, Hachim K, Medkouri G, Benghanem MG, Ramdani B. (2007). Chronic lead poisoning: A “forgotten” cause of renal disease Saudi J Kidney Dis Transplant 18: 83–86.
Bergeson LL. (2008). The proposed lead NAAQS: Is consideration of cost in the clean air Act future. Environmental Quality Management 18: 79–84.
Billings RJ, Berkowitz RJ, Watson G. (2004). Teeth. Pediatrics 113: 1120–1127. Breeher L, Mikulski MA, Czeczok T, Leinenkugel K, Fuortes LJ. (2015). A cluster of lead poisoning among consumers of Ayurvedic medicine. Int J Occup Environ Health. Apr 6:2049396715Y0000000009. [Epub ahead of print]
Brunton LL, Goodman LS, Blumenthal D, Buxton I, Parker KL. ed. (2007). Goodman and Gillmans Manual of Pharmacology and Therapeutics. Mc- Graw Hill Professional.
Büsselberg D, Evans ML, Haas HL, Carpenter DO. (1993). Blockade of mammalian and invertebrate calcium channels by lead. Neurotoxicology 14: 249–58.
Casaret LJ, Klaassen CD, Doull, J. ed. (2007). Toxic effects of metals. Casarett and Doull’s Toxicology: The Basic Science of Poisons (7th ed.) McGraw Hill Professional.
Case Studies in Environmental Medicine Lead (Pb) Toxicity: How are People Exposed to Lead? Agency for Toxic Substances and Disease Registry. Archived on 19-09-2014.
Centers for Disease Control and Prevention (CDC). (2009). CDC Fourth National Report on Human Exposure to Environmental Chemicals. Updated Tables. Atlanta, GA: US Department of Health and Human Services.
Centers for Disease Control and Prevention (CDC). (2012). Low-Level Lead Exposure Harms Children: A Renewed Call for Primary Prevention. Retrieved 19 Sept. 2014.
Centers for Disease Control and Prevention. Folk Medicine. http: //www.cdc. gov/nceh/lead/tips/folkmedicine.htm Retrieved 23 Sept. 2014.
Chisolm J, Harrison H. (1956). The Exposure of Children to Lead. J Am Acad Pe- diatrics 18: 943–958.
Cleveland LM. Minter ML, Cobb KA, Scott AA, German VF. (2008). Lead hazards for pregnant women and children. Am J Nurs 108: 40– 49.
Cohen AR, Trotzky MS.; Pincus D. (1981). Reassessment of the Microcytic Ane- mia of Lead Poisoning. Pediatrics 67: 904–906.
Dart RC, Hurlbut KM, Boyer-Hassen LV. (2004). Lead. In Dart, RC. Medical Toxicology (3rd ed.). Lippincott Williams and Wilkins.
Deperiky, D., & Hadiguna, R. A. (2020). Supply Chain Management Agroindustry: Sebuah Literature Review. I N V E N T O R Y Industrial Vocational E-Journal on Agroindustry, 1, 1–7.
Dobrakowski M, Kasperczyk J, Romuk E, Prokopowicz A, Birkner E. (2014). The influence of beta-carotene on homocysteine level and oxidative stress in lead-exposed workers. Med Pr 65: 309–16.
Ekong, EB, Jaar BG, Weaver VM. (2006). Lead-related nephrotoxicity: a review of the epidemiologic evidence. Kidney International 70: 2074–84.
Fang JY, Wang PW, Huang CH, Hung YY, Pan TL. (2014). Evaluation of the hepatotoxic risk caused by lead acetate via skin exposure using a proteomic approach. Proteomics 14: 2588–2599.
Febria, F. A., Zakaria, I. J., Syukriani, L., Rahayu, P., & Fajri, M. A. (2016). The highest mercury-resistant bacteria as a mercury remediator from gold mining soil in West Sumatera, Indonesia. Available Online www.Jocpr.com Journal of Chemical and Pharmaceutical Research, 8(1), 394–397. https://doi.org/10.13140/RG.2.1.2305.8324
Febria, F. A., Octavelly, V., & Zakaria, I. J (2018). Isolation and Heavy Metals Bacterial Resistant Test from Former Bauxite Mining at Bintan Island. Asian Jr. of Microbiol. Biotech. Env. Sc. 20(1), 341-344.
Febria, F. A., & Aziza, R. (2022). Exopolysaccharides-Producing Biofilm Bacteria from Submerged Seawater Substrate for Bioremediation of Heavy Metal Contamination. Pakistan Journal of biological sciences: PJBS, 25(1), 9-14.
Fitri, W. E., & Rahmatiqa, C. (2020). Chlorella Vulgaris dalam penyerapan logam berat. In A. Putra (Ed.), Monograf: Chlorella Vulgaris dalam penyerapan logam berat (pp. 1–71). Al-fannani Publisher.
Fitri, W. E., Rahmatiqa, C., & Putra, A. (2021). Bioremediasi Logam Berat Pb (II) Dan Cu (II) Pada Air Lindi Menggunakan Chlorella Vulgaris. Dalton: Jurnal Pendidikan Kimia Dan Ilmu Kimia, 4(I), 58–69. https://doi.org/http://dx.doi.org/10.31602/dl.v4i1.4877
Flora G, Gupta D, Tiwari A. (2012). Toxicity of lead: A review with recent updates. Interdiscip Toxicol 5: 47–58.
Flora, SJ, Mittal M, Mehta A. (2008). Heavy metal-induced oxidative stress & its possible reversal by chelation therapy. Indian J Med Res 128: 501–23.
Flores-Montoya MG, Sobin C. (2014). Early chronic lead exposure reduces exploratory activity in young C57BL/6J mice. J Appl Toxicol 35(7): 759–765.
Fujita H, Nishitani C, Ogawa K. (2002). Lead, chemical porphyria, and heme as biological mediators. Tohoku J Exp Med 196(2): 53–64.
Grant LD. (2009). Lead and compounds. IN Lippmann, M. Environmental Toxicants: Human exposure and their health effects (3rg ed.) Wiley-Interscience.
He Y, von Lampe K, Wood L, Kurti M. (2015). Investigation of lead and cadmium in counterfeit cigarettes seized in the United States. Food Chem Toxic- col 81: 40–45.
Henretig FM. (2006). Lead. IN Golgfrank, LR. Goldfrank’s Toxicologic Emer- agencies (8th ed.) McGraw Hill Professional.
Hu H, Shih R, Rothenberg S, Schwartz BS. (2007). The Epidemiology of Lead Toxicity in Adults: Measuring Dose and Consideration of Other Methodologic Issues. Environ Health Perspect 115: 455–62.
Jacobs DE, Clickner, RP, Zhou JY, Viet SM, Marker DA, Rogers JW, Zeldin DC, Broene P. Friedman W. (2002). The prevalence of lead-based paint hazards in U.S. housing. Environ Health Perspect 110: A599–606.
Ja-Liang L, Dan-Tzu L, Kuang-Hung H, Chun-Chen Y. (2003). Environmental Lead Exposure and Progression of Chronic Renal Diseases in Patients without Diabetes. N Engl J Med 348: 277–86.
Jurdziak M, Gać P, Martynowicz H, Poręba R. (2015). The function of the respiratory system was evaluated using selected spirometry parameters in persons occupationally exposed to lead without evident health problems. Environ Toxic- col Pharmacol 39: 1034–1040.
Karri SK, Saper RB, Kales SN. (2008). Lead Encephalopathy Due to Traditional Medicines. Curr Drug Saf 3: 54–9.
Kasperczyk S, Dobrakowski M, Kasperczyk A, Romuk E, Rykaczewska- Czerwińska M, Pawlas N, Birkner E. (2015). Effect of N-acetylcysteine administration on homocysteine level, oxidative damage to proteins, and levels of iron (Fe) and Fe-related proteins in lead-exposed workers. Toxicol Ind Health. [Epub ahead of print]
Kosnett MJ. (2005). Lead. In Brent, J. Critical Care Toxicology: Diagnosis and Management of the Critically Poisoned Patient. Gulf Professional Publishing. ISBN 0-8151-4387-7.
Kosnett MJ. (2006) Lead in Olson, K.R. Poisoning and Drug Overdose (5th ed.) McGraw Hill Professional.
Kosnett MJ. (2007) Heavy metal Intoxication and chelators. In Katzung BG. Basic and Clinical Pharmacology. McGraw Hill Professional.
Kosnett, MJ, Wedeen RP, Rothenberg SJ, Hipkins KL, Materna BL, Schwartz BS, Hu H, Woolf A. (2007). Recommendations for Medical Management of Adult Lead Exposure. Environ Health Perspect 115: 463–71
Landrigan PJ, Schechter CB, Lipton JM, Fahs MC, Schwartz J. (2002). Environmental pollutants and disease in American children. Environ Health Per- spect 110: 721–8.
Levin R, Brown MJ, Kashtock ME. Jacobs DE, Whelan EA, Rodman J, Schock MR, Padilla A, Sinks T. (2008). Lead Exposures in U.S. Children, 2008: Implications for Prevention. Environ Health Perspect 116: 1285–1293.
Li C, Pan Z, Xu T, Zhang C, Wu Q, Niu Y. (2014). Puerarin induces the upregulation of glutathione levels and nuclear translocation of Nrf2 through PI3K/Akt/GSK-3β signaling events in PC12 cells exposed to lead. Neurotoxi- col Teratol 46: 1–9.
Lin JL, Huang PT (1994). Body Lead stores and urate excretion in men with chronic renal disease. J Rheumatol 21: 705–709
Lv C, Xu Y, Wang J, Shao X, Ouyang J, Li J. (2015). Dysplastic changes in erythroid precursors as a manifestation of lead poisoning: report of a case and review of the literature. Int J Clin Exp Pathol 8: 818–23.
Mahaff ey KR. (1990). Environmental lead toxicity: nutrition as a component of the intervention. Environ Health Perspect 89: 75–78.
Mai FM. (2006). Beethoven’s terminal illness and death. J R Coll Physicians Ed- in. 36: 258–63
Mañay N, Cousillas AZ, Alvarez C, Heller T. (2008). Lead contamination in Uru- guay: the “La Teja” neighborhood case. Rev Environ Contam Toxicol 195: 93–115.
Marino PE, Landrigan PJ, Graef J, Nussbaum A, Bayan G, Boch K, Boch, S. (1990). A case report of lead paint poisoning during a renovation of a Victorian farmhouse. Am J Pub Health 80: 1183–1185.
Mason LH, Harp JP, Han DY. (2014). Pb Neurotoxicity: Neuropsychological Effects of Lead Toxicity. BioMed Res Int. Article ID 840547, 8 pages
http: //dx.doi.org/10.1155/2014/840547.
Merill JC, Morton JJP, Soileau SD. (2007). Metals. In Hayes, A.W. Principles and Methods of Toxicology (5th ed.) CRC Press.
Meyer PA, McGeehin MA, Falk H. (2003). A global approach to childhood lead poisoning prevention. Int J Hyg Environ Health 206: 363–369
Mohsen V, Derek RS, Ping-Chi H. (2011). How does lead induce male infertility, Iran J Reprod Med 9: 1–8.
Moore MR. (1977). Lead in drinking water in soft water areas--health hazards. Sci Total Environ 7: 109–115.
Mycyk M, Hryhorcu D, Amitai Y. (2005) “Lead” In Erickson TB, Ahrens WR, Aks S, Ling L. Paediatric Toxicology: Diagnostic and management of the Poisoned Child. Mcgraw Hill Professional.
Navas-Acien A, Guallar E, Silbergeld EK, Rothenberg SJ. (2007). Lead Exposure and Cardiovascular Disease--A Systematic Review. Environ Health Per- spect 115: 472–82.
Needleman H. (2004). Lead poisoning. Annu Rev Med 55: 209–22 Needleman HL, Schell A, Bellinger D, Leviton A, Allred EN. (1990). The long-term effects of exposure to low doses of lead in childhood an 11-year follow-up report. N Engl J Med 322: 83–88.
Nevin R (2007). Understanding international crime trends: the legacy of pre-school lead exposure. Environ Res 104: 315–336.
Nevin R. (2000). How lead exposure relates to temporal changes in IQ, violent crime, and unwed pregnancy. Environ Res 83: 1–22.
Park SK, O’Neill MS, Vokonas PS, Sparrow D, Wright RO, Coull B, Nie H, Hu H, Schwartz J. (2008). Air Pollution and Heart Rate Variability: Effect Modief Cations by Chronic Lead Exposure. Epidemiology 19: 111–120.
Patrick L. (2006). Lead toxicity, a review of the literature. Part 1: Exposure, evaluation, and treatment. Altern Med Rev 11: 2–22.
Pearce JMS. (2007). Burton’s line in lead poisoning. Eur Neurol. 57: 118–119. Pearson HA, Schonfeld DJ. (2003). Lead. In Rudolph, C.D. Rudolph’s Pediatrics (21st ed.) McGraw Hill professional.
Pratiwi, D. Y. (2020). Dampak Pencemaran Logam Berat (Timbal, Tembaga, Merkuri, Kadmium, Krom) terhadap Organisme Perairan dan Kesehatan Manusia. Jurnal Akuatek, 1(1), 59–65.
Putra, A., & Fitri, W. E. (2016). Karakterisasi Pertukaran Ion Timbal (II) dengan Kalsium pada Proses Biosorpsi Alga Hijau Cladophora fracta. Jurnal Ipteks Terapan, 10(2), 103–111. https://doi.org/10.22216/jit.2016.v10i2.421
Putra, A., & Fitri, W. E. (2021). Effectivity Removal of Cadmium Toxic Metals from Leachate Using Chlorella Vulgaris Non-Living Cell. International Conference on Nursing, Midwifery, Medical Laboratory Technology, Public Health, and Health Information Management (SeSICNiMPH 2021), 39(Advances in Health Sciences Research), 345–349. https://doi.org/10.2991/ahsr.k.211026.069
Putra, A., Fauzia, S., Arief, S., & Zein, R. (2022). Preparation, characterization, and adsorption performance of activated rice straw as a bio adsorbent for Cr (VI) removal from aqueous solution using a batch method. Desalination and Water Treatment, 264(32), 121–132. https://doi.org/https://doi.org/10.5004/dwt.2022.28562
Putra, A. (2022). Studi Kinetika Adsorpsi Ion Cr (VI) Menggunakan Serbuk Jerami Padi Teraktivasi. Prosiding SNST Fakultas Teknik, 12(1), 26-30.
Rogan WJ, Dietrich KN, Ware JH, Dockery DW, Salganik M, Radcliff e J, Jones RL, Ragan NB, Chisolm JJ Jr, Rhoads GG. (2001). The effect of chelation therapy with succimer on neuropsychological development in children ex- posed to lead. N Engl J Med 344(19): 1421–1426.
Rossi E. (2008). Low-Level Environmental Lead Exposure – A Continuing Challenge. Clin Biochem Rev 29: 63–70.
Roy A, Queirolo E, Peregalli F, Mañay N, Martínez G, Kordas K. (2015). Association of blood lead levels with urinary F2-8α isoprostane and 8-hydroxy-2-deoxy-guanosine concentrations in first-grade Uruguayan children. Envi- ron Res 140: 127–135.
Rubin R, Strayer DS. ed. (2008). Environmental and Nutritional Pathology. Rubins pathology; Clinicopathologic Foundations of Medicine (5th ed.) Lippincott Williams & Wilkins.
Sanborn MD, Abelsohn A, Campbell M, Weir E. (2002). Identifying and managing adverse environmental health effects: 3. Lead exposure. CMAJ 166: 1287–1292.
Sanders T, Liu Y, Buchner V, Tchounwou PB. (2009). Neurotoxic Effects and Biomarkers of Lead Exposure: A Review. Rev Environ Health 24: 15–45.
Schoeters G, Hond ED, Dhooge W, Larebeke NV, Leijs M. (2008). Endocrine Disruptors and Abnormalities of Pubertal Development. Basic & Clinical Pharmacology & Toxicology 102: 168–175.
Wani, A. L., Ara, A., & Usmani, J. A. (2015). Lead toxicity: A review. Interdisciplinary Toxicology, 8(2), 55–64. https://doi.org/10.1515/intox-2015-0009
Woolf AD, Goldman R, Bellinger DC. (2007). Update on the clinical management of childhood lead poisoning. Pediatr Clin North Am 54: 271–294
Wright LF, Saylor RP, Cecere FA. (1984). Occult lead intoxication in patients with gout and kidney disease. J Rheumatol 11: 517–520.
Xu J, Yan HC, Yang B, Tong LS, Zou YX, Tian Y. (2009). Effects of lead exposure on hippocampal metabotropic glutamate receptor subtype 3 and 7 in development rats. J Negat Results Biomed 8: 5.
Yu CC, Lin JL, Lin-Tan DT. (2004). Environmental Exposure to Lead and Progression of Chronic Renal Diseases: A Four-Year Prospective Longitudinal Study. J Am Soc Nephrol 15: 1016–1022.
Zein, R., & Putra, A. (2021). Pemanfaatan Jerami Padi Sebagai Penyerap Ion Logam Pb (II). In Monograf: Pemanfaatan Jerami Padi Sebagai Penyerap Ion Logam Pb (II) (1st ed., pp. 1–45). Andalas University Press.
Zhang H, Liu Y, Zhang R, Liu R, Chen Y. (2014). Binding Mode Investigations on the Interaction of Lead (II) Acetate with Human Chorionic Gonadotropin. J Phys Chem B 118: 9644–9650
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