THE EFFECT OF LIFETSYLE ON LUTEINIZING HORMONE LEVELS, TESTOSTERONE LEVELS AND INFERTILITY IN OBESITY MEN

Angga Bhaim Ibrahim

doi:10.30633/jkms.v13i2.1617

THE EFFECT OF LIFETSYLE ON LUTEINIZING HORMONE LEVELS, TESTOSTERONE LEVELS AND INFERTILITY IN OBESITY MEN

Angga Bhaim Ibrahim

Abstract

Obesity is a state of imbalance between incoming energy and outgoing energy over a long period of time (Hartono, 2008). Obesity is becoming an epidemic throughout the world, both in developed and developing countries, and two-thirds suffer from obesity (Stefan, 2010). The increase in obesity will reach 50% in 2025 for developed countries (Sudoyo, 2009). According to WHO (2013), there are 2.1 billion obese people in the world, Indonesia ranks 10th with a total of 40 million obese people, after the United States, China, India, Russia, Brazil, Mexico, Egypt, Germany and Pakistan. Was from Riskesdas (2013), adolescents aged 13-21 years in Indonesia suffer from 10.8% obesity, 8.3% obesity and 2.5% very obesity.

In obesity, there is an increase in adiponectin and a decrease in resistin and RBP-4, resulting in the formation of fat cell adipocytes which affect the hormone testosterone (Ganong, 2012). Testosterone (17-hydroxyandrost-4-en-3) is the main androgen hormone synthesized in the testes and adrenal cortex. Testosterone is synthesized primarily in the leydig cells, whereas the leydig cells are regulated by luteinizing hormone (LH). The amount of testosterone synthesized is regulated by the hypothalamus-pituitary-testicular axis (Muller, 2013). When testosterone levels are low, gonadotropin-releasing hormone (GnRH) is released by the hypothalamus, which stimulates the anterior pituitary gland to release LH stimulating the testes to synthesize the hormone testosterone. Finally, it increases testosterone levels through negative feedback (Ganong, 2012). Some of the factors that cause a decrease in hormone levels are lifestyle such as smoking, stress and consuming alcohol.

The conclusion of the study is that there is an effect of lifestyle on LH levels, the hormone testosterone and infertility in obese men. Suggestions for future researchers to conduct research with a larger sample size.

Keywords

Obesitas, Lutinizing Hormon, Testosteron, Infertilitas, Pria

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References

Aini, S. dan Shovitri, M. (2018). Studi Awal Pemanfaatan Bawang Putih yang dihitamkan sebagai Antibakteri. Jurnal Sains dan Seni ITS

Allan Mazur, Ronny Westerman, And Ulrich Mueller. (2008). Is Rising Obesity Causing A Secular (Age-Independent) Decline In Testosterone Among American Men, Plos ONE: Public Library Of Science. J Med 2014.

Azar, A. (2005). Perbedaan Lipid Darah Pada Asupan Lemak Normal Dan Lemak Tinggi Pada Anak Dengan Obesitas Usia 6-7 Tahun, UNDIP : Semarang.

AA Yassin And G Doros. (2013). Testosterone Therapy In Hypogonadal Men Results In Sustained And Clinically Meaningful Weight Loss.Clinical Obesity : Wiley-Blackwell, John Wiley & Sons. J Med 2014.

Baxendale, PM, MJ, Reed Dan VHT James. Testosteron Dalam Air Liur Pria Normal Dan Itu Hubungan Dengan Terikat Dan Kadar Testosteron Total Dalam Plasma. Jurnal. Endokrin.87:46 P-4P.1980

Carla DB Fernandez, Fernanda F Bellentani, And Wilma DG Kempinas. (2011). Diet-Induced Obesity In Rats Leads To A Decrease In Sperm Motility. Reproductive Biology And Endocrinology : RB&E Biomed Central. J Med 2014.

Ganong, WF. (2012). Buku Ajar Fisiologi Kedokteran, Edisi 22, Hal 396-417 dan 441-450, EGC : Jakarta.

Farid Saad, Antonio Aversa, And Louis J Gooren. (2013). Testosterone As Potential Effective Therapy In Treatment Of Obesity In Men. With Testosterone Deficiency: A Review. Current Diabetes Reviews Bentham Science Publishers. J Med 2014.

Franck Mauvais-Jarvis. (2012). Estrogen and androgen receptors: Regulators of fuel homeostasis and emerging targets for diabetes and obesity. Trends in endocrinology and metabolisme: TEM. Author Manuscript. NIH Public Access.

Kimura, S., Yen, C.-T., Min, H.-P., Nan, W.-S., Ying, J.-L. (2017) ‘Black Allium sativum: A critical review of its production, bioactivity, and application’, Journal of Food and Drug Analysis. doi: 10.1016/j.jfda.2016.11.003.

Lee, Y.-M. (2009) ‘Antioxidant effect of garlic and aged Black Allium sativum in animal model of type 2 diabetes mellitus’, Nutrition Research and Practice. doi: 10.4162/nrp.2009.3.2.156.

Mary, et al. (2007). Ilmu Gizi, PT Gelora Aksara Pratama, Erlangga : Jakarta.

Maryunani, A. (2010). Biologi Reproduksi Dalam Kebidanan, Edisi 1, Hal 159-184 & 233-240, CV. Trans Info Media : Jakarta.

Mustofa, S. (2010). Sindrom Metabolik dan Defisiensi Testosteron, Biosintesis Testosteron dan Obesitas Testosteron. Fakultas Kedokteran Universitas YARSI, Vol. 2, Jakarta.

Nugroho, et al. (2011). Ilmu Gizi Menjadi Sangat Mudah, Edisi ke 2, EGC : Jakarta.

Robert L Rosenfield, MD And Brian Bordini, MD. (2011). Evidence That Obesity And Androgens Have Independent And Opposing Effects On Gonadotropin Production From Puberty To Maturity.Brain Research, Author Manuscript, NIH Public Access. J Med 2014.

Sabine Rohrmann, Meredith S. Shiels, And Elizabeth A. Platz. (2010). Body Fatness And Sex Steroid Hormone Concentrations In US Men – Results From NHANES III. Cancer Causes & Control : CCC Author Manuscript NIH Public Access. J Med 2014.

Seo, Y. J. (2009) ‘Effect of garlic and aged Black Allium sativum on hyperglycemia and dyslipidemia in animal model of type 2 diabetes mellitus’, Journal of Food Science and Nutrition. doi: 10.3746/jfn.2009.14.1.001.

Shi M - D, Chao J - K, Ma M - C, Hao L - J, Dan Chao I- C. (2014). Faktor Yang Terkait Dengan Hormon Seks Dan Disfungsi Ereksi Pada Pria Taiwan Peserta Dengan Obesitas. J Med 2014 Sex ; 11:230-239.

Staron, RS, RS Hikida, FC Hagerman, Gadudley Dan R.Murray. Manusia Serat Otot Rangka Ketik Beban Kerja Yang Beragam. J. Histochem. Cytochem.32:146-152.1.984

Stephanie Cabler, Ashok Agarwal, And Stefan S. Du Plessis. (2010). Obesity: Modern Man's Fertility Nemesis.Asian Journal Of Andrology. Medknow Publications. J Med 2014.

Stephen D. Hursting, John Digiovanni, And Nathan A. Berger (2013). Obesity, Energy Balance And Cancer: New Opportunities For Prevention. Cancer Prevention Research (Philadelphia, Pa.). Author Manuscript NIH Public Access. J Med 2014.

Steven, S. (2008). Pengantar Riset Pendekatan Ilmiah Untuk Proses Keperawatan, Jakarta : EGC. Peterjemah Palupi Widyastuti.

Sudoyo, AW.(2009). Buku Ajar Ilmu Penyakit Dalam. Hal. 319-356. EGC : Jakarta.

Sugondo. (2006). Ilmu Penyakit Dalam, Edisi. IV Jilid III.EGC : Jakarta.

Sulistia & Gunawan. (2012). Farmakolgi Dan Terapi, Edisi 5, Hal 468-480, FKUI : Jakarta.

Shalender Bhasin, MD, Guneet K. Jasjua, PHD, And Thomas G. Travison, PHD. (2014). Sex Hormone–Binding Globulin, But Not Testosterone, Is Associated Prospectively And Independently With Incident Metabolic Syndrome In Men. Diabetes Care American. Diabetes Association. J Med 2014.

Svartberg, J, Midtby, M., Bona, K.H, Sundsfjord, J, Juakimses, R.M., & Jorde, R. (2003). The association of age, lifestyle factor and chronic disease with testosterone in men : the tromso study. European journal of endocrinology, 149, 145-152.

Tom R Trinick, Mark R Feneley, And Malcolm (2011). Carruthers International Web Survey Shows High Prevalence Of Symptomatic Testosterone Deficiency In Men. The Aging Male. Taylor & Francis. J Med 2014.

WHO. (2013). Prevalensi Obesitas, Geneva : Jurnal The Lancet.

DOI: http://dx.doi.org/10.30633/jkms.v13i2.1617