PENGARUH MEROKOK TERHADAP HORMON TESTOSTERON PADA LAKI-LAKI USIA DIATAS 40 TAHUN

Ibrahim Angga Nawawi

Abstract


Testosteron adalah hormon androgen pada laki-laki dan hormon ini akan menurun sesuai dengan bertambahnya usia. Penurunan kadar testosteron ini mulai terjadi pada usia 40 tahun. Dua puluh persen laki-laki berusia 60-80 tahun, dan tiga puluh lima persen laki-laki berusia 80 tahun mempunyai konsentrasi testosteron total di bawah batas normal yaitu 350 ng/dL. Penurunan kadar testosteron akan menimbulkan berbagai gangguan fisik dan psikologis. Banyak faktor yang menyebabkan penurunan kadar testosteron salah satunya adalah perokok. Laki-laki perokok mempunyai risiko 2 kali lipat untuk mengalami penurunan kadar hormon testosteron. Rokok mengandung banyak bahan kimia yang sangat berbahaya bagi perokok aktif. Menurut WHO, ada 13 milyar perokok, dan Indonesia menduduki peringkat ke-4 jumlah perokok terbanyak di dunia dengan jumlah sekitar 141 juta orang. Pada hasil survei MMAS ditemukan perokok memiliki resiko 24% terjadinya disfungsi ereksi akibat penurunan hormon testosteron. Tujuan penelitian untuk mengetahui pengaruh merokok terhadap hormon testosteron pada laki-laki berusia diatas 40 tahun. Penelitian ini observasional, dengan pendekatan cross sectional dengan total sampling berjumlah 36 orang laki-laki berusia diatas 40 tahun dan perokok aktif. Penelitian ini telah dilaksanakan dari bulan April 2017 sampai Oktober 2017 di RW X Perumahan Mega Permai dan Laboratorium Biokimia FK Unand untuk pemeriksaan hormon testosteron.  Analisa data diolah dengan sistem komputerisasi dengan uji statistic regresi linier sederhana derajat penolakan 5% ( p =0,05). Hasil penelitian tentang kebiasaan merokok didapatkan nilai mean 19,69 batang, median 18,50 batang, minimum 5 batang dan maximum 42 batang. Sedangkan hormone testosterone dengan nilai mean 11,303 nmol/L, median 10,250 nmol/L, minimum 7,5 nmol/L dan maximum 18,1 nmol/L. Terdapat pengaruh nilai signifikan kebiasaan merokok dengan hormone testosteron, di tandai nilai pada F hitung 30,309 dengan sig. 0,000 ≤ 0,05, artinya variabel kebiasaan merokok dapat mempengaruhi variabel hormone testosteron secara signifikan. Pengaruh kebiasaan merokok terhadap hormone testosterone adalah sebesar 68,7%.

 

Kata Kunci      : Hormon Testosteron, Kebiasaan Merokok

 

SMOKING EFFECT ON TESTOSTERON HORMONES ON THE MAN AGES IN 40 YEARS

                                                   ABSTRACT

Testosterone is an androgene hormone in males and this hormone decreases with age. This decrease in testosterone levels begins at 40 years of age. Twenty percent of men aged 60-80 years, and thirty-five percent of men aged 80 years have testosterone concentrations below the limit of 350 ng / dL. Decrease in testosterone levels will cause various physical and psychological disorders. Many that cause a decrease in testosterone levels one of them is a smoker. Male smokers have a 2-fold risk of decreasing testosterone levels. Cigarettes contain many chemicals that are very dangerous for active smokers. According to WHO, there are 13 billion smokers, and Indonesian is ranked the 4th largest number of smokers in the world with about 141 million people. In the survey results found MMAS smokers have a 24% risk of erectile dysfunction due to decreased testosterone. The aim of the study was to investigate the effect of smoking on testosterone in men over 40 years old. This study was observational, with cross sectional approach with sampling amounting to 36 men over the age of 40 years and active smokers. This research has been conducted from April 2017 to October 2017 in RW X Mega Permai and Biokimia Laboratory FK Unand for examination of testosterone. Was analysis processed by computerized system with simple linear regression statistic test of 5% rejection degree (p = 0,05). Result of research about smoking got mean value 19,69 stem, median 18,50 stem, minimum 5 rod and maximum 42 rod. While the hormone testosterone with a mean value of 11.303 nmol / L, median 10,250 nmol / L, a minimum of 7.5 nmol / L and a maximum of 18.1 nmol / L. There is of significant value of smoking with testosterone hormone, in mark value at F count 30,309 with sig. 0.000 ≤ 0,05, meaning that smoking variable can variable of testosterone hormone significantly. The of smoking on testosterone hormone is 68,7%.


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DOI: http://dx.doi.org/10.30633/882220172017%25p1

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