Debie Anggraini


Leptospirosis is a zoonotic disease with the main source of transmission in humans from rats, dogs, cattle, and pigs. Leptospira icterohemorrhagiae is a Leptospira serovar that infects rats. Leptospires live in the kidneys/urinary tract of these animals without causing disease and continuously flowing in the urine. Leptospira examination was carried out using a phase contrast microscope or dark field. Leptopira requires special media and conditions to grow and its culture takes a long time. Serological examination is the main basis in the diagnosis of leptospirosis. The reference method of serological examination for leptospirosis is the microscopic agglutination test (MAT).

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Aktories, K., Fakultät, M., Pharmakologie, K., Albert-, A. I., Freiburg, L., & Cooper, M. D. (2012). Current Topics in Microbiology and Immunology Series Editors, 386.

Bharti, A. R., Nally, J. E., Ricaldi, J. N., Matthias, M. A., Diaz, M. M., Lovett, M. A., … Vinetz, J. M. (2003). Leptospirosis: A zoonotic disease of global importance. Lancet Infectious Diseases.

Bhatia, M., & Umapathy, B. L. (2015). Deciphering leptospirosis-a diagnostic mystery: an insight. International Journal of Medical Research & Health Sciences, 4(3), 693.

Bhatia, M., Umapathy, B., & Navaneeth, B. (2015). An evaluation of dark field microscopy, culture and commercial serological kits in the diagnosis of leptospirosis. Indian Journal of Medical Microbiology, 33(3), 416.

Cosson, J. F., Picardeau, M., Mielcarek, M., Tatard, C., Chaval, Y., Suputtamongkol, Y., … Morand, S. (2014). Epidemiology of Leptospira Transmitted by Rodents in Southeast Asia. PLoS Neglected Tropical Diseases, 8(6).

Desai, S., van Treeck, U., Lierz, M., Espelage, W., Zota, L., Sarbu, A., … Jansen, A. (2009). Resurgence of field fever in a temperate country: an epidemic of leptospirosis among seasonal strawberry harvesters in Germany in 2007. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 48(6), 691–697.

Dutta TK & Christopher M, 2005, Leptospirosis-An Overview, JAPI, 53: 545-51.

Hochedez, P., Theodose, R., Olive, C., Bourhy, P., Hurtrel, G., Vignier, N., … Cabié, A. (2015). Factors Associated with Severe Leptospirosis, Martinique, 2010–2013. Emerging Infectious Diseases, 21(12), 2221–2224.

Infect, I. J., Panaphut, T., Domrongkitchaiporn, S., & Thinkamrop, B. (2002). Prognostic factors of death in leptospirosis: a prospective cohort study in Khon Kaen, Thailand. International Journal of Infectious Diseases, 6(1), 52–59.

Levett DN, 2006, Leptospira spp in Principles and Practice of Clinical Bacteriology, Second Edition, Editor: Coillespie SH, Hawkey PM, USA: John Wiley & Sons, pp: 463-9.

Ministry Of Health Malaysia. (2011). Guidelines for the Diagnosis, Management, Prevention and Control of Leptospirosis in Malaysia. (K. Verasahib, Ed.) (1st ed.). malaysia: DISEASE CONTROL DIVISION DEPARTMENT OF PUBLIC HEALTH MINISTRY OF HEALTH MALAYSIA. Retrieved from 2011.pdf

Shivakumar, S., & Krishnakumar, B. (2006). Diagnosis of Leptospirosis - Role of MAT. Journal of Association of Physicians of India, 54(APR.), 338–339.

Vijayachari, P., Sugunan, A. P., & Shriram, A. N. (2008). Leptospirosis: An emerging global public health problem. Journal of Biosciences, 33(4), 557–569.

Vinetz JM, 2012, Leptospirosis in Infectious Diseases, Harrison’s Principles of Internal Medicine, 18th Edition, Editor: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, USA: Mc-GrawHill, 1392-6.

WHO. (2009). Leptospirosis situation in the WHO South-East Asia Region. World Health Organization Regional Office for South-East Asia, 1–7.

Yilmaz, H., Turhan, V., Yasar, K. K., Hatipoglu, M., Sunbul, M., & Leblebicioglu, H. (2015). Characteristics of leptospirosis with systemic inflammatory response syndrome: a multicenter study. Annals of Clinical Microbiology and Antimicrobials, 14, 54.

Zein U, 2009, Leptospirosis dalam Buku Ajar Ilmu Penyakit Dalam Edisi V, Editor: Sudoyo AW, Setiyohadi B, Alwi I, Simadibrata M, Setiati S, Jakarta : Pusat Penerbitan Departemen Ilmu Penyakit Dalam FK UI.



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