Tinjauan Potensi Ektrak Pare (Momordica charantia L.) dalam Menurunkan Kadar Glukosa Darah dan proteksi disfungsi spermatogenik

Rina Regita, Albert M. Hutapea, Mangatas Silaen, Subang Aini Nasution

Abstract


Latar  Belakang:  Diabetes  melitus  (DM)  merupakan penyakit  metabolik  yang  ditandai  dengan  gejala hiperglikemia  akibat  gangguan  sekresi  insulin. Penyebab  utama  diabetes  melitus  tipe  2  adalah kelainan  metabolisme  yang  ditandai  dengan  resistensi reseptor  insulin,  berkurangnya  kemampuan  sel pankreas  mensekresi  insulin,  Saat  ini,  penggunaan obat herbal makin diminati karena dipercaya memiliki efek samping yang rendah. Pare  (Momordica  charantia L.) diketahui kaya akan  mineral  nabati  kalsium dan  fosfor,  serta  karotenoid , Selain itu kandungan lain pare memiliki saponin,  polisakarida,  triterpen,  protein, vitamin,  mineral,  flavonoid,  asam  askorbat,  dan  steroid. Saat ini Pare banyak  ditanam  dan  dimakan  di daerah  tropis,  subtropis,  dan  beriklim  sedang.  Tujuan penelitian  ini  adalah  untuk  mengetahui  pengaruh ekstrak  pare  (Momordica  charantia  L.)  terhadap penurunan  gula  darah,  resistensi  insulin,  dan  signaling  fosfatidilinositol, efek farmakokinetik dan farmakodinamik serta pengaruhnya didalam memproteksi dari disfungsi spermatogenik.  Metode:  Studi  literatur  review  dari  jurnal  terkait. Hasil:  Berdasarkan  penelitian  yang  dilakukan  diketahui  bahwa ekstrak  pare  mempunyai  pengaruh  terhadap  gula  darah, resistensi  insulin,  efek farmakokinetik dan farmakodinamik serta pengaruhnya didalam memproteksi dari disfungsi spermatogenik. Kesimpulan:  Ekstrak  pare  mempunyai  potensi  sebagai  obat herbal  antidiuretik

Full Text:

PDF

References


Akhter, Rupaly, Imrul Hasan Rasel, and

Mohammad Saiful Islam. 2018.

“Antidiabetic Effect of Bitter Melon/Kerala

(Momordica Charantia) in Alloxan Induced

Diabetic Rat.” Research in Agriculture

Livestock and Fisheries 5(3):373–79. doi:

3329/ralf.v5i3.39586.

Akmal, Tubagus, and Lucy Sasongko. n.d.

INFLUENCE OF Momordica Charantia

(L.) ON THE PHARMACOKINETICS AND

PHARMACODYNAMICS OF

GLICLAZIDE IN ALLOXAN-INDUCED

DIABETIC RATS MODEL. Vol. 8.

Anon. 2013. “Five Questions on the IDF Diabetes

Atlas.” Diabetes Research and Clinical

Practice 102(2):147–48. doi:

1016/j.diabres.2013.10.013.

Chang, Chi-I., Shi-Yie Cheng, Annisa Oktafianti

Nurlatifah, Wei-Wen Sung, Jing-Hong Tu,

Lin-Lee Lee, and Hsueh-Ling Cheng. 2021.

“Bitter Melon Extract Yields Multiple

Effects on Intestinal Epithelial Cells and

Likely Contributes to Anti-Diabetic

Functions.” International Journal of

Medical Sciences 18(8):1848–56. doi:

7150/ijms.55866.

Damanik, Gustiany Nadya, and Hadyanto Lim.

Literatur Review The Effect of Pare

(Momordica Charantia L.) Fruit Extract

Fraction on Reducing Blood Sugar, Insulin

Resistance and Phosphatidyl Inositol 3

Kinase (PI3K) Signalling in Male Rats

(Rattus Novergicus) Streptozotocin-Induced

Hyperglycemia.

Jia, Yanan, Zihan Xue, Yajie Wang, Yangpeng

Lu, Ruilin Li, Nannan Li, Qirou Wang, Min

Zhang, and Haixia Chen. 2021. “Chemical

Structure and Inhibition on α-Glucosidase

of Polysaccharides from Corn Silk by

Fractional Precipitation.” Carbohydrate

Polymers 252:117185. doi:

1016/j.carbpol.2020.117185.

Liu, Zhuo, Jing Gong, Wenya Huang, Fuer Lu,

and Hui Dong. 2021. “The Effect of

Momordica Charantia in the Treatment of

Diabetes Mellitus: A Review.” Evidence Based Complementary and Alternative

Medicine 2021.

Mahmoud, Mona Fouad, Fatma El Zahraa Z. El

Ashry, Nabila N. El Maraghy, and Ahmed

Fahmy. 2017. “Studies on the Antidiabetic

Activities of Momordica Charantia Fruit

Juice in Streptozotocin-Induced Diabetic

Rats.” Pharmaceutical Biology 55(1):758–

doi: 10.1080/13880209.2016.1275026.

Oyelere, Sunday Faith, Oluwatobi Hezekiah

Ajayi, Titilayo Eunice Ayoade, George

Bueno Santana Pereira, Bolaji Charles Dayo

Owoyemi, Ajibola Olaoluwa Ilesanmi, and

Olalekan Amos Akinyemi. 2022. “A

Detailed Review on the Phytochemical

Profiles and Anti-Diabetic Mechanisms of

Momordica Charantia.” Heliyon 8(4).

Pratiwi, I., and Sasongko. 2019.

“ Pengaruh Pemberian Ekstrak Buah Par

e (Momordica Charantia L. Fructus) Ter

hadap Farmakokinetika Dan Farmakodin

amika Metformin Pada Tikus Model Re

sistensi Insulin.”

Institut Teknologi Bandung.

Richter, Erika, Thangiah Geetha, Donna Burnett,

Tom L. Broderick, and Jeganathan Ramesh

Babu. 2023. “The Effects of Momordica

Charantia on Type 2 Diabetes Mellitus and

Alzheimer’s Disease.” International

Journal of Molecular Sciences 24(5):4643.

doi: 10.3390/ijms24054643.

Rohajatien, Ummi, Harijono, Teti Estiasih, and

Endang Sri Wahyuni. 2018. “Bitter Melon

(Momordica Charantia L) Fruit Decreased

Blood Glucose Level and Improved Lipid

Profile of Streptozotocin Induced

Hyperglycemia Rats.” Current Research in

Nutrition and Food Science 6(2):359–70.

doi: 10.12944/CRNFSJ.6.2.11.

Shimada, Takumi, Fumihiro Kato, Dinia Rizqi

Dwijayanti, Takuma Nagata, Akito

Kinoshita, Tetsuya Okuyama, Mikio

Nishizawa, and Eri Mukai. 2022. “Bitter

Melon Fruit Extract Enhances Intracellular

ATP Production and Insulin Secretion from

Rat Pancreatic β -Cells.” British Journal of

Nutrition 127(3):377–83. doi:

1017/S0007114521001082.

Soliman, Gamal A., Rehab F. Abdel-Rahman,

Hanan A. Ogaly, Hassan N. Althurwi,

Reham M. Abd-Elsalam, Faisal F.

Albaqami, and Maged S. Abdel-Kader.

“Momordica Charantia Extract

Protects against Diabetes-Related

Spermatogenic Dysfunction in Male Rats:

Molecular and Biochemical Study.”

Molecules 25(22). doi:

3390/MOLECULES25225255.

White, Pandora E., Ewelina Król, Artur

Szwengiel, Małgorzata Tubacka, Dawid

Szczepankiewicz, Halina Staniek, John B.

Vincent, and Zbigniew Krejpcio. 2011.

“Effects of Bitter Melon and a Chromium

Propionate Complex on Symptoms of

Insulin Resistance and Type 2 Diabetes in

Rat Models.” doi: 10.1007/s12011-020-

-y/Published.

Yadav, M. 2010.

“’Studi Komplementer Dan Perbandingan

Aktivitas Hipoglikemik Dan Antihipergl

ikemik Berbagai Ekstrak Biji Eugenia Ja

mbolana, Buah Momordica Charantia, G

ymnema Sylvestre, Dan Biji Trigonella

Foenum Graecum Pada Tikus.”

Biokimia Dan Bioteknologi Terapan.

Yue, Jiayin, Jing Xu, Jiaqing Cao, Xiaoshu

Zhang, and Yuqing Zhao. 2017.

“Cucurbitane Triterpenoids from

Momordica Charantia L. and Their

Inhibitory Activity against α-Glucosidase,

α-Amylase and Protein Tyrosine

Phosphatase 1B (PTP1B).” Journal of

Functional Foods 37:624–31. doi:

1016/j.jff.2017.07.041.




DOI: http://dx.doi.org/10.30633/jsm.v7i1.2476

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.




Jurnal Kesehatan Saintika Meditory
Published by Stikes Syedza Saintika Padang 

Pusat Penelitian dan Pengabdian Masyarakat, STIKes SYEDZA Saintika Padang

Jl. Prof. Dr. Hamka No. 228 Air Tawar Timur Padang - Sumatera Barat

Phone: 082384992512
Email: lppmsyedza@gmail.com


  

View My Stats
situs toto

situs toto

situs toto

slot88

situs toto

situstoto

rokokbet

situs toto

slot gacor

https://ojs.semeiosis.com.br/

situs toto

slot88

https://app.smartcongress.co/

situs toto

scatter hitam

situs toto

slot88

https://mathedu.web.id/

situs toto

toto 4d

toto 4d

situs toto

situs togel

slot88

slot gacor

situs toto

situs toto

situs toto

situs toto

slot88

slot gacor

toto 4d

situs toto

toto 4d

situs toto

slot gacor

slot gacor

slot gacor

slot gacor

slot gacor

slot gacor

slot gacor

situs toto

situs toto

slot88

situs toto

situs toto

situs toto

situs toto

slot88

situs toto

situs toto

situs toto

situs togel

situs toto

situs toto

situs togel

slot88

situs toto

slot gacor

situs toto

situs toto

situs toto

situs toto

slot gacor

slot gacor

slot gacor

slot gacor

slot gacor

situs toto

For4D

For4D

For4D

For4D

For4D

For4D

slot gacor

https://absimasfinance.id/

https://jastan.id/

https://www.acset.id/

https://www.chandra-asri.it.com/

https://www.wilmarcahayaindonesia.it.com/

https://www.mncfinancialservices.it.com/

https://www.eaglehighplantations.id/

https://www.woorifinance.org/

https://www.nusakonstruksi.org/

https://reviewlawsocialsciences.com/

https://jees.in/

https://kabarmedan.github.io/

slot88

situs toto

slot gacor

situs toto

toto slot

demo slot

link slot gacor

situs toto

situs toto slot

situs toto

Demo pg

https://www.guiadoexcel.com.br/

https://www.glossacontact.org/

http://jurnal.dbp.my/

https://www.stepnetwork.org/

https://niph.org.kh/

toto 4d

slot jepang

https://unitomo.id/

https://theusajournals.com/

Slot88

Toto 4D

https://imigrasimedanbelawan.com/

https://pafikotaprabumulih.org/

https://pafibekasikota.org/

https://heylink.me/slot-gacor-nota4d/

Slot Online

Toto 4d

Situs Toto

situs toto

situs toto

slot88

situs toto

slot gacor

slot88

situs toto

situs toto

slot gacor

slot88

slot88

slot777

slot gacor

demo slot

slot88

rokokbet

rokokbet

slot777

situs toto

slot777

https://tokoweb.co.id/

https://kadinkotadepok.org/

https://ejurnal.staiha.ac.id

https://taodalin.com/

https://theusajournals.com/

https://unitomo.id/

situs toto

slot88

situs toto

situs toto

https://kuburantua.com/

toto 4d

paito hk

toto 4d

nana4d

toto 4d

toto 4d

toto 4d

https://mantratechno.com/

https://digtaldesa.id/

https://pafikodepok.org/

https://pafikodepok.com/

https://pafikotegal.org/

https://pafikotegal.com/

https://himpsibali.org/

https://himpsiriau.org/

https://himpsipadang.org/

https://himpsidepok.org/

https://himpsitegal.org/

https://wingscorp.org/

https://gudanggaramtbk.org/

https://leminerale.id/

https://upnvj.org/

https://eatandys.id/

https://itpln.org/

https://institutpendidikan.org/

https://tamansafari.id/

https://balisafarimarinepark.id/

https://pafipemkotanggerang.org/

https://pafipemkolamongan.org/

https://pafipemkojember.org/

https://thewhiskyexchange.id/

https://unsika.org/

https://kadinkotajakarta.org/

https://himpsijakarta.org/

https://himpsikalimantan.org/

https://himpsisumbar.org/

https://himpsikaltim.org/

https://himpsibandung.org/

https://univgadjahmada.id/

https://garudafood.org/

https://sydneyaihealthcare.org/

https://globonews.gr/

https://worldjourneyexperiences.com/

https://www.humbiol.org/

https://jaita.org/

https://www.kabarpramuka.com/

https://scientificrtj.com/

https://mck.gr/

https://journalaihealth.uk/

https://ijsmien.com/

https://beshabhusa.com/

https://bangalorenotes.com/

https://www.eidos.co.in/

https://valezaco.com/

toto macau

nana4d

toto 4d

https://www.tenutaantonini.it/

https://nerj.org/

https://anagennisierapetras.gr/

http://technology.adrpublications.in/

http://science.adrpublications.in/

https://kemensosri.id/

https://ijaos.com/

https://ikjri.id/

http://umsuac.id/

https://periodicosulbrabra.org/

https://lawfirmryanmaulana.com/

situs toto

TOTO 4D

FOR4D/

FOR4D/

FOR4D/

For4D

Situs Toto 4D

Toto 4D

Situs Toto

https://casinoroyalezone.com/

https://mail.perth-lawyers.family/

for4d

for4d

shiowla

toto 4d

slot 4d

slot 4d

slot 4d

slot 4d

https://karosatu.id/

https://suara-sumut.id/

https://www.zonajakarta.id/

https://iaipusat.id/

https://iaisemarang.id/

https://iaijember.id/

https://iaikudus.id/

https://iaijepara.id/

https://konikotaklaten.id/

https://konisumut.id/

For4D

For4D

For4D

For4D

For4D

For4D

For4D

Toto 4D

Toto 4D

Toto 4D

Nono4D

Nono4D

Nono4D

https://kadinkalsel.org/

https://kadinkalsel.id/

https://kadinprovjakarta.id/

https://mitrakeluargadepok.id/

https://unusia.id/

https://pelindobanten.id/

https://pelindopetikemas.id/

https://pelindojakarta.id/

https://pelindomedan.id

https://pelindotanjungperak.id/

https://kadinkaltara.org/

https://kadinprovkalsel.com/

https://stimarami.id/

Slot777

https://roanokebusinessnetworking.org/

https://ourcamchats.com/

toto slot

toto 4d

https://katib.ac.pk/

https://www.smleqbank.com/

https://www.capitollimoaustin.com/

https://ftm.edu.co/

okewla

slot777

https://kadinjaksel.org/

https://kadintangerangkota.org/

https://kadingorontalokota.org/

https://kadinjateng.id/

https://kadinmanado.id/

https://radiosuaradiponegoro.com/

https://jasamaritim.id/

https://literasihukum.or.id/

https://meraukekab.id

https://desaarborek.id

https://himpsisurabaya.org

https://liedschatten.com/

https://hsnrj.org/

https://ijse.sha.edu.eg/

https://uzconferences.org/

Slot bet 200

Slot bet kecil

Slot88

Bet4D

Slot88

Slot777

Slot dana

Togel 4d

Togel viral

Slot demo

Bet4D

Toto 4d

Toto 4d

Bet4D

Toto 4d

Slot88

Slot thailand

Slot88

Toto 4d

Slot88

Bet4d

https://pastipolinema.com/

https://kadinsemarang.id/

https://pelindotanjungbalai.id/

https://web3tot.com/

Slot777

Slot777

Slot777

Rokokslot

Toto 4D

Situs Toto

https://poltekpelbanten.id/

toto 4d

toto 4d

mega4d

https://flavourfusion.co.in/

rokokslot

rokokslot

https://pafigalungung.org/

https://bpindonesia.com/

https://www.rsubj.org/

https://www.lesprivatinsan.org/

https://insightsjlss.com/

https://www.istes.org/

https://jkbn.co.id/

https://pafinabirekota.org/

https://pafisiakkota.org/

https://pafitigaraksakota.org/

https://pafikabsentani.org/

https://himpsijembrana.org/

https://himpsidenpasar.org/

https://himpsikeckintamani.org/

https://journal.infopolis.gr/

https://ijonse.net/

https://insightsjhr.com/

https://medscicatalyst.org/

https://togelmatauang.com/

https://slotvipmatauang.com/

https://folsomfelines.org/

https://68.183.224.199/

https://frenchysymphony.com/

https://lunetwork.org/

https://formationsantedroit.org/

https://teamromany.com/

https://hidetanakake.com/

https://profheshamsalaheldin.com/

https://neighboursreview.com/

https://brittanygilbertdesign.com/

https://menlotool.com/

https://leadnepal.com/

https://universitaspertamina.id/

https://jaibdd.com/

https://ojs.avesjournals.com/

Slot Gacor 88

slot dana

https://jaibdd.com/

Slot Bet Kecil

https://ijetcsit.org/

https://bujhss.bahria.edu.pk/

https://lbbcendikia.org/

https://harcoglodok.org/

https://rozezshop.org/

https://kaputama.id/

https://pancabudi.org/

https://uimedan.org/

https://pafikabmuarosijunjung.org/

https://pafilimokota.org/

https://pafidesapancoranmas.org/

https://pafikabtobelo.org/

https://pafibatusangkarkota.org/

https://aimlrxiv.org/

https://ejma.uk/

https://pafimesujikota.org/

https://pafimagetankota.org/

https://pafislawikota.org/

https://pafi-garutkota.org/

https://pafijakutkota.org/

https://pafisalakkota.org/

https://himpsimaluku.org/

https://himpsisulteng.org/

https://himpsijayapura.org/

https://pecindonesia.id/

https://newprimagama.id/

https://balimedhospital.id/

https://baliroyalhospital.id/

https://rscitrahusada.id/

https://rsia-grhabunda.id/

https://rsmramata.id/

https://rsroyaltaruma.id/

https://changinternationalcircuit.com/

https://www.vansthailand.com/

https://kingpowerbangkok.com/

https://erawanhotel.org/

https://mayoraindah.org/

https://mitratel.org/

https://indocement.org/

slot dana

slot bet 200

slot dana

slot dana

slot dana

slot dana

matauangslot

FOR4D

slot dana

matauangslot

slot777

slot dana

slot88

slot777

https://icsww.muet.edu.pk/

https://womenentrepreneurs.biz/

https://marketsdigital.store/

slot777

slot gacor hari ini

slot gacor

slot toto

toto slot

https://feb.uhamka.ac.id/

situs toto

slot gacor

idn slot

slot gacor 2025

slot dana

https://e-library.stikespasapua.ac.id/

slot gacor

slot togel

slot gacor

saudara168

saudara168

slot gacor 2025

slot depo 5k

slot gacor

barbartoto

barbartoto

situs toto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

barbartoto

slot777

barbartoto

slot777

situs toto

https://ffs.uhamka.ac.id/

https://ft.uhamka.ac.id/

https://fisip.uhamka.ac.id/

https://jurnal.stikesabi.ac.id/

https://feb.uhamka.ac.id/

https://fk.uhamka.ac.id/

https://smbcpersada.co.id/

https://webs.stikesabi.ac.id/

https://womenentrepreneurs.biz/

https://marketsdigital.store/

https://icsww.muet.edu.pk/

https://www.sindhttb.gov.pk/

https://product.devbio.in/

idnslot

linkslot gacor

https://dkpp.cilegon.go.id/

https://satpolpp.cilegon.go.id/

https://dinsos.cilegon.go.id/

https://disporapar.cilegon.go.id/

https://dlh.cilegon.go.id/

https://dpk.cilegon.go.id/

https://insp.cilegon.go.id/

https://setda.cilegon.go.id/

https://www.dindikbud.cilegon.go.id/

https://diskominfo.cilegon.go.id/

idn slot

idn slot

toto 4d

https://lancer.co.id/

toto 4d

https://univ.sttberitahidup.ac.id/

https://sarapanbola.com/

slot777

https://jcicom.usim.edu.my/

slot resmi

toto 4d

https://www.intaranvillamanagement.co.id/

https://www.zonakerja.online/

slot resmi

https://siakad.sttberitahidup.ac.id/

slot gacor 5000

toto 4d

slot 2025

situs toto

idn slot

idn slot

idn slot

slot depo 5k

slot gacor hari ini

slot88

situs toto

slot qris

idn slot

https://taka-rei.jp/

https://healthgrass.in/

slot gacor 2025

https://nushaa.activedigital.id/

slot gacor 2025

toto slot

https://data.plasapay.com/

https://myblog.plasapay.com/

https://tagrt.plasapay.com/

https://pln.plasapay.com/

https://ksp.plasapay.com/

https://informasi.plasapay.com/

https://etiket.plasapay.com/

https://piutang.plasapay.com/

https://bank.plasapay.com/

https://plasapay.com/pos/

slot resmi

idn slot

https://www.univ.sttberitahidup.ac.id/

slot deposit 5000

https://weshootvision.com/

situs toto

slot gacor hari ini

toto slot

situs toto

https://10situstogelterpercaya.id/

Situs Toto

https://truedata.co.in/

https://carleton.com.au/

https://jiz.jmx.mybluehost.me/

https://panesarco.uk/

https://azzamirsenior.cerdig.com/

https://sdiassalaftahfidzulquran.cerdig.com/

slot jepang

https://unitomo.id/

https://theusajournals.com/

https://www.glossacontact.org/

slot jepang

https://unitomo.id/

https://theusajournals.com/

https://jaabjournal.org/

slot thailand

https://www.glossacontact.org/

http://jurnal.dbp.my/

https://www.hsuf-journal.com.ua/

https://imsventures.com/

https://theusajournals.com/

https://www.glossacontact.org/

http://jurnal.dbp.my/

https://www.stepnetwork.org/

https://theusajournals.com/

https://niph.org.kh/

slot dana

https://infometrokota.id/

https://suara-sumut.id/

https://karosatu.id/

https://www.tanyapepsodent.id/

slot 4d

Togel viral

https://skdacademia.org/

Toto 4D

https://ngmc.ac.in/

https://skdacademia.org/

https://ngmc.org/

situs toto

situs toto

for4d

situs togel

slot bet 200

situs toto

for4d

situs toto

https://sman11-jkt.sch.id/

Slot88

Toto 4D

Rokokslot

Rokokslot

Rokokslot

Rokokslot

Rokokslot

Rokokslot

Rokokslot

Rokokslot

Rokokslot

Parlay

Slot88

Sbobet

Slot777

Togel Resmi

situs togel

situs toto

situs toto

situs toto

situs toto

situs toto

situs toto

toto 4d

slot gacor

slot gacor

slot88

slot88

slot88

idn slot

slot thailand

situs toto

https://ma-labor.uinjambi.ac.id/api/

slot gacor

slot gacor

slot gacor

slot gacor

slot gacor

slot gacor

slot gacor

slot777

slot gacor

slot gacor

slot88