IMMATURE PLATELET FRACTION (IPF) EXAMINATION IN DENGUE FEVER: LITERATURE REVIEW

Uli Masuliyah Indarwati; Defi Nurul Hayati

doi:10.30633/jsm.v8i2.30597

IMMATURE PLATELET FRACTION (IPF) EXAMINATION IN DENGUE FEVER: LITERATURE REVIEW

Uli Masuliyah Indarwati, Defi Nurul Hayati

Abstract

Dengue Fever occurs in patients with varying degrees of severity. One of the symptoms that may appear is thrombocytopenia, which is characterized by a low platelet count. Therefore, it requires special attention in laboratory examinations. The Immature Platelet Fraction (IPF) is one of the hematology test parameters that has potential as a supporting parameter for platelet examination. Evaluation of the IPF value in laboratory tests contributes to the differential diagnosis of thrombocytopenia cases. The purpose of this literature review is to identify the IPF examination in laboratory and to describe the IPF profile in DHF cases. The search method was conducted through PubMed, Google Scholar, and Scopus, with articles reviewed from the years 2016 to 2025. Based on the literature review, IPF examination can be performed using a hematology analyzer. The IPF parameter has an inverse relationship with the platelet parameter increase in IPF value occurs alongside a decrease in platelet count.Conclusion: The IPF parameter can be considered a supporting parameter for platelet examination, for monitoring the severity of thrombocytopenia, and as a predictor of platelet recovery

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References

Ahmad, J., Noor, S. M., Mustapha, S. Z., & Idris, F. (2022). Estimation of a cut-off value for immature platelet fraction (IPF) in predicting platelet recovery in dengue patients with thrombocytopenia. Malaysian Journal of Pathology, 44(3), 499–508.

Ali, I., Graham, C., & Dempsey-Hibbert, N. C. (2019). Immature platelet fraction as a useful marker in the etiological determination of thrombocytopenia. Experimental Hematology, 78(1), 56–61. https://doi.org/10.1016/j.exphem.2019.09.001

Anetsberger, A., Bernlochner, I., Jungwirth, B., Blobner, M., Meyer, B., Kochs, E. F., Bongiovanni, D., Schmid, S., Langgartner, C., Baumgart, L., & Gempt, J. (2023). Association of immature platelets with perioperative complications in neurosurgery. Platelets, 34(1). https://doi.org/10.1080/09537104.2023.2185462

Archuleta, S., Chia, P. Y., Wei, Y., Syed-Omar, S. F., Low, J. G., Oh, H. M., Fisher, D., Ponnampalavanar, S. S. L., Wijaya, L., Kamarulzaman, A., Lum, L. C. S., Tambyah, P. A., Leo, Y. S., & Lye, D. C. (2020). Predictors and clinical outcomes of poor platelet recovery in adult dengue with thrombocytopenia: A multicenter, prospective study. Clinical Infectious Diseases, 71(2), 383–389. https://doi.org/10.1093/cid/ciz850

Asha, J., Baiju, N. M., Innah, S. J., Rafi, A., & John, B. M. (2022). Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center. Asian Journal of Transfusion Science, 17(1), 21–27. https://doi.org/10.4103/ajts.AJTS_24_20

Bongiovanni, D., Schreiner, N., Gosetti, R., Mayer, K., Angiolillo, D. J., Sibbing, D., Holdenrieder, S., Anetsberger, A., Von Scheidt, M., Schunkert, H., Laugwitz, K. L., Schüpke, S., Kastrati, A., Fegers-Wustrow, I., & Bernlochner, I. (2023). Immature Platelet Fraction Predicts Adverse Events in Patients with Acute Coronary Syndrome: The ISAR-REACT 5 Reticulated Platelet Substudy. Arteriosclerosis, Thrombosis, and Vascular Biology, 43(2), E83–E93. https://doi.org/10.1161/ATVBAHA.122.318614

Buttarello, M., Mezzapelle, G., Freguglia, F., & Plebani, M. (2020). Reticulated platelets and immature platelet fraction: Clinical applications and method limitations. International Journal of Laboratory Hematology, 42(4), 363–370. https://doi.org/10.1111/ijlh.13177

Ezhilarasu, R., Shobana, K., Siddharth, S., & Kumar, R. S. (2020). Platelet Indices Assay as an Indicator of Recovery in Dengue affected Children. International Journal of Academic Medicine and Pharmacy, 438–443. https://doi.org/10.47009/jamp.2023.5.2.92

Ferreira, F. L. B., Colella, M. P., Medina, S. S., Costa-Lima, C., Fiusa, M. M. L., Costa, L. N. G., Orsi, F. A., Annichino-Bizzacchi, J. M., Fertrin, K. Y., Gilberti, M. F. P., Ozelo, M. C., & De Paula, E. V. (2017). Evaluation of the immature platelet fraction contribute to the differential diagnosis of hereditary, immune and other acquired thrombocytopenias. Scientific Reports, 7(1), 1–8. https://doi.org/10.1038/s41598-017-03668-y

Georgakopoulou, V. E., Mermigkis, D., Mantzouranis, K., Damaskos, C., Melemeni, D., Alafaki, E. A., Petsinis, G., Garmpis, N., Karakou, E., Garmpi, A., Lekkakou, A., Sklapani, P., Trakas, N., Chatzikyriakou, R., & Tsiafaki, X. (2020). Evaluation of Immature Platelet Fraction in Lower Respiratory Tract Infections: A Retrospective Study. Cureus, 12(7). https://doi.org/10.7759/cureus.9227

Goel, G., Semwal, S., Khare, A., Joshi, D., Amerneni, C. K., Pakhare, A., & Kapoor, N. (2021). Immature Platelet Fraction: Its Clinical Utility in Thrombocytopenia Patients. Journal of Laboratory Physicians, 13(03), 214–218. https://doi.org/10.1055/s-0041-1729471

Hamad, M. A., Krauel, K., Schanze, N., Gauchel, N., Stachon, P., Nuehrenberg, T., Zurek, M., & Duerschmied, D. (2022). Platelet Subtypes in Inflammatory Settings. Frontiers in Cardiovascular Medicine, 9(April), 1–9. https://doi.org/10.3389/fcvm.2022.823549

Holinstat, M. (2017). Normal platelet function. Cancer and Metastasis Reviews, 36(2), 195–198. https://doi.org/10.1007/s10555-017-9677-x

Ileandea, B. V., Nurhayati, D., Sunardi, A., & Hikam, M. (2025). Correlation of High Fluorescence Lymphocyte Count and Thrombocytopenia in Dengue Fever Infection. Indonesian Journal of Clinical Pathology and Medical Laboratory, 31(3), 224–228. https://doi.org/10.24293/ijcpml.v31i3.2344

Irfan, U., Minhas, A. M., Hashmi, H. R., Siddique, M. U., Insari, R., Imran, A., & Chughtai, A. S. (2024). Immature Platelet Fraction: A Novel Hematological Parameter for Predicting Prognosis of Dengue Patients. J. HaematolStem Cell Res, 4(1), 166–170.

Jeon, M. J., Yu, E. S., Kang, K. W., Lee, B. H., Park, Y., Lee, S. R., Sung, H. J., Yoon, S. Y., Choi, C. W., Kim, B. S., & Kim, D. S. (2020). Immature platelet fraction based diagnostic predictive scoring model for immune thrombocytopenia. Korean Journal of Internal Medicine, 35(4), 970–978. https://doi.org/10.3904/KJIM.2019.093

Joshi, N., Gupta, L., & Chatterjee, R. (2023). Anaesthetic management of pregnant patients with severe dengue fever for emergency caesarean section - A case series and review. Indian Journal of Clinical Anaesthesia, 10(3), 295–300. https://doi.org/10.18231/j.ijca.2023.059

Kanwal, R., Shuja, U., Naz Zafar, A., Mansha, H., Haji, Y., & Khalid, E. (2025). the Immature Platelet Fraction; an Early Recovery Indication of Thrombocytopenia in Dengue Fever. Insights-Journal of Health and Rehabilitation, 3(2 (Health & Allied)), 82–88. https://doi.org/10.71000/ykfd8x16

Kashiwagi, H., Kuwana, M., Murata, M., Shimada, N., Takafuta, T.,

Yamanouchi, J., Kato, H., Hato, T., & Tomiyama, Y. (2024). Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition. International Journal of Hematology, 119(1), 1–13. https://doi.org/10.1007/s12185-023-03672-1

Khazali, A. S., Hadrawi, W. H., Ibrahim, F., Othman, S., & Nor Rashid, N. (2024). Thrombocytopenia in dengue infection: mechanisms and a potential application. Expert Reviews in Molecular Medicine, 26. https://doi.org/10.1017/erm.2024.18

Lee, Y. K., Jeon, K., Kim, M., Lee, E., Lee, J., Lee, J.-S., & Kim, H. J. (2018). Immature Platelet Fraction: A Useful Marker for Identifying the Cause of Thrombocytopenia and Predicting Platelet Recovery. Blood, 132(Supplement 1), 128–128. https://doi.org/10.1182/blood-2018-99-113202

Looi, K. W., Matsui, Y., Kono, M., Samudi, C., Kojima, N., Ong, J. X., Tan, C. A., Ang, C. S., Tan, P. H. Y., Shamnugam, H., Sekaran, S. D., Syed Omar, S. F., & Lum, L. C. S. (2021). Evaluation of immature platelet fraction as a marker of dengue fever progression. International Journal of Infectious Diseases, 110, 187–194. https://doi.org/10.1016/j.ijid.2021.07.048

Low, G. K. K., Jiee, S. F., Masilamani, R., Shanmuganathan, S., Rai, P., Manda, M., Omosumwen, O. F., Kagize, J., Gavino, A. I., Azahar, A., & Jabbar, M. A. (2023). Routine blood parameters of dengue infected children and adults. A meta-analysis. Pathogens and Global Health, 117(6), 565–589. https://doi.org/10.1080/20477724.2022.2161864

Nandi, M., & Gupta, N. (2024). Immune Thrombocytopenia Following Dengue Fever. Dubai Medical Journal, 7(1), 9–15. https://doi.org/10.18502/dmj.v7i1.17495

Noel, M. M., Feugray, G., Kasonga, F., Buchonnet, G., Daliphard, S., Barbay, V., Bera, E., Le Cam Duchez, V., & Billoir, P. (2023). Stability over time of immature platelet fraction and comparison between EDTA and citrated whole blood samples. Journal of Clinical Laboratory Analysis, 37(13–14), 1–7. https://doi.org/10.1002/jcla.24946

Ong-misa, M. M. S., Garcia, R. D. J., Uy-aragon, M. J., & Arkoncel-adapon, M. A. (2018). Pediatric Infectious Disease Society of the Philippines Journal Ong-Misa MM , Garcia RD , Uy-Aragon MJ & Arkoncel-Adapon MA . Relationship Between Immature Platelet Fraction and Platelet Count among Pediatric Patients with Dengue Fever : A Prospective Cro. 19(1), 14–23.

Saidah, F., & Sjakti, H. A. (2018). Peran Pemeriksaan Immature Platelet Fraction dalam Imun Trombositopenia. Sari Pediatri, 20(3), 190. https://doi.org/10.14238/sp20.3.2018.190-6

Uchino, S., Saita, Y., Wada, A., Kobayashi, Y., Wakayama, T., Nishio, H., Fukusato, S., Momoi, Y., Nakajima, R., Ikeda, H., & Ishijima, M. (2021). The immature platelet fraction affects the efficacy of platelet rich plasma therapy for knee osteoarthritis. Regenerative Therapy, 18, 176–181. https://doi.org/10.1016/j.reth.2021.06.004

Yang, T. H., Tsai, C. K., Wang, H. Y., Ko, P. S., Chien, S. H., Lin, T. A., Chen, W. C., Hsu, T. L., Yeh, C. M., Lu, C. I., Lin, W. J., Chen, Y. J., Liu, C. J., & Liu, C. Y. (2024). Early prediction of platelet recovery with immature platelet fraction in patients receiving hematopoietic stem cell transplantation. Annals of Hematology, 103(11), 4661–4670. https://doi.org/10.1007/s00277-024-05951-1

Yasuda, I., Saito, N., Suzuki, M., Umipig, D. V., Solante, R. M., de Guzman, F., Sayo, A. R., Yasunami, M., Koizumi, N., Kitashoji, E., Sakashita, K., Ng, C. F. S., Smith, C., & Ariyoshi, K. (2021). Unique characteristics of new complete blood count parameters, the Immature Platelet Fraction and the Immature Platelet Fraction Count, in dengue patients. PLoS ONE, 16(November), 1–15. https://doi.org/10.1371/journal.pone.0258936

Zhang, Y., Wang, Z., Zhou, P., & Zhang, H. (2025). From reticulated platelets to immature platelet fraction: structure, function, and clinical applications. Platelets, 36(1). https://doi.org/10.1080/09537104.2025.2467383

DOI: http://dx.doi.org/10.30633/jsm.v8i2.30597